Overexpression of CD47 is associated with brain overgrowth in 16p11.2 deletion syndrome
Jingling Li, Thomas Brickler, Allison M. Banuelos, Kristopher David Marjon, Anna Shcherbina, Sravani Banerjee, Jing Tan Bian, Cyndhavi Narayanan, Irving L. Weissman, Sundari Chetty
The paper investigates the role of CD47 overexpression in 16p11.2 deletion syndrome, showing it contributes to brain overgrowth by inhibiting phagocytosis in neural progenitor and oligodendrocyte progenitor cells.
Proceedings of the National Academy of Sciences · Apr 8, 2021Peer-reviewedNeuroscience