Pre-existing chromatin accessibility primes δ-cells for injury-induced endocrine plasticity
Jo Graesslin, Prateek Chawla, Padmapriya Subramanian, Anuradha Rajendran, Emilie Ida Christine Walda, Alexander Froschauer, Nikolay Ninov, Jan Philipp Junker
This study shows that pre-existing chromatin accessibility in δ-cells enables their conversion into hybrid cells after β-cell loss in zebrafish, facilitating endocrine plasticity.
bioRxiv · Jul 10, 2026 · PreprintDevelopmental Biology