Epigenetic Mechanisms Inhibit Smad7 and Contribute to Fibrosis in Crohn's Disease
Chao Li, Karnam Murthy, Jaime Bohl, Emily Rivet, Nicole Wieghard, John Kuemmerle
This study identifies epigenetic and post-translational mechanisms that silence Smad7 in fibrostenotic Crohn's disease, promoting TGF-beta1 signaling and fibrosis.
bioRxiv · Nov 10, 2026 · PreprintCell Biology