Histone modifications define distinct nucleosome positions in cell-free DNA
Yukun Ou, Gunsagar Singh Gulati, Caroline F. Tyndall, Medha Pandey, Ji-Heui Seo, Ze Zhang, Zhenjie Jin, Garyoung Gary Lee, Rashad Nawfal, Taylor A. Hoggood, Sadia D. Shahbazi, John Ludwig, Ziwei Zhang, Élio Ibrahim, Gaelle Nafeh, , Sylvan C. Baca
This paper identifies histone modification-associated nucleosome positions in cfDNA that correlate with tumor fraction and cancer state across multiple cancers.
bioRxiv · Oct 28, 2026 · PreprintCancer Biology