Functional characterization of the biogenic amine transporter system on human macrophages
Phillip M. Mackie, Adithya Gopinath, Dominic M. Montas, Alyssa M. Nielsen, Rachel Ann Nolan, Kaitlyn Runner, Stephanie M. Matt, John McNamee, Joshua E. Riklan, Kengo Adachi, Andria L. Doty, Adolfo Ramirez‐Zamora, Long Yan, Peter J. Gaskill, Wolfgang J. Streit, , Habibeh Khoshbouei
This study identifies a DAT-mediated immuno-modulatory mechanism in human macrophages, showing dopamine transport regulates innate immune responses to LPS and is disrupted in disease.
bioRxiv · Sep 8, 2021 · PreprintNeuroscience