WNT signaling in human pluripotent stem cells promotes HDAC2-dependent epigenetic programs and development of retinoic acid-responsive mesoderm
Bao Thai, Elizabeth J. Sargent, Stephanie A. Luff, Colin A. Fields, Jared M. Churko, Jonathan N. Young, Anthony Bosco, Christopher M. Sturgeon, Deepta Bhattacharya
This study shows that WNT signaling in hPSCs promotes mesoderm development through HDAC2-dependent epigenetic programs and RA responsiveness, enhancing T cell generation.
Stem Cell Reports · Jun 18, 2026Peer-reviewedDevelopmental Biology