Extensional Flow Microfluidics Reveal Size-Dependent Core-Shell Mechanical Heterogeneity in Pancreatic Tumor Spheroids
Sara Ghanbarpour Mamaghani, Timothy M Costa, Ethan C Wagner, Soroush Kargar, Jonathan P Celli, Joanna B Dahl
This study uses microfluidics to show that pancreatic tumor spheroids of different sizes exhibit distinct mechanical behaviors, with larger spheroids showing core-shell heterogeneity.
bioRxiv · Nov 6, 2026 · PreprintBioengineering