Author

Jonathan Sheehan

Vanderbilt University

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Genetics· 1

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Research Focus:benchmarking· 1 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

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Jens MeileriD· 1 shared John A. CapraiD· 1 shared John Phillips· 1 shared Jonathan Kropski· 1 shared Joy Cogan· 1 shared R. Michael SivleyiD· 1 shared Timothy S. BlackwelliD· 1 shared William S. BushiD· 1 shared

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Jens MeilerORCID

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1 paper

Recent·Most cited

GeneticsThe American Journal of Human GeneticsPeer-reviewedFeb 15, 2018

Comprehensive Analysis of Constraint on the Spatial Distribution of Missense Variants in Human Protein Structures

R. Michael Sivley, Jonathan Kropski, Jonathan Sheehan…·John A. Capra

The paper analyzes the spatial distribution of missense variants in human protein structures to classify variants of unknown significance, finding disease-causing variants cluster more than benign ones.

79 citationstop 3%

humanprotein structure