Human heart organoids reveal a regenerative strategy for mitochondrial disease
Minh Duc Pham, Arka Provo Das, Yue Wang, Despina Stefanoska, Ting Yuan, Chaonan Zhu, Meiqian Wu, Alfredo Cabrera‐Orefice, Luka Nicin, Shane Bell, Mathias Langner, U. Gärtner, Oliver M. Russell, Jonathan Ward, Mirko Peitzsch, , Jaya Krishnan
The paper uses human heart organoids to model mitochondrial disease and identifies a drug that improves mitochondrial function and tissue contractility.
bioRxiv · Dec 21, 2025 · PreprintCell Biology