Critically Ill Children Frequently Receive Medications with Established but Unused Pharmacogenomic Guidelines: Actionable Findings from an Integrated Electronic Medical Record and Exome Sequencing Study
Noelle Lynch, Naama Elefant, Anya Revah‐Politi, Andrew S. Geneslaw, Jaimee Beckett, Joseph Blake Wall, Carlos Aguilar Breton, Maya Sabatello, Steven G. Kernie, Hülya Bayır, Ali G. Gharavi, Joshua E. Motelow
This study finds that many critically ill children receive medications with established pharmacogenomic guidelines, but exome sequencing identifies actionable PGx variants that could improve treatment.
medRxiv · Jul 20, 2026 · PreprintGenetic & Genomic Medicine