Spatial analysis reveals the cellular microenvironments and mechanisms of inflammation and kidney injury in acute interstitial nephritis
Megan Leila Baker, Vijayakumar R. Kakade, Tifanny Budiman, Marlene Weiß, Joseph M. Cunningham, Sagar S. Sadarangani, Gabriel Lerner, Gilbert Moeckel, Avi Z. Rosenberg, Chirag R. Parikh, Yuval Kluger, Dennis G. Moledina, Lloyd G. Cantley
The paper identifies the CXCL9-CXCR3 axis and NAMPT as key drivers of inflammation and kidney injury in acute interstitial nephritis using spatial transcriptomics and imaging.
Nature Communications · Aug 27, 2026Peer-reviewedImmunology