Engineering a light-responsive, orthogonal Lon protease in E. coli for targeted protein degradation
Cristian Coriano-Ortiz, Lily A. Fenton, Josh Kome, Mary J. Dunlop
The paper develops a light-responsive, orthogonal Lon protease in E. coli for targeted protein degradation, showing it can degrade proteins in both growth phases and respond to light intensity.
bioRxiv · Jun 19, 2026 · PreprintSynthetic Biology