Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA
Rebecca Martin, Claudia Y. Espinoza, Christopher R. L. Large, Joshua Rosswork, Cole Van Bruinisse, Aaron W. Miller, Joseph C. Sanchez, Madison A. Miller, Samantha Paskvan, Gina M. Alvino, Maitreya J. Dunham, M. K. Raghuraman, Bonita J. Brewer
The paper identifies a replication error mechanism called ODIRA that generates inverted copy number variants through template switching at replication forks, using yeast as a model system.
PLoS Genetics · Jan 4, 2024Peer-reviewedGenomics