Author

Josia Pool

Wageningen University & Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aditi BatraiD· 2 shared J. Arjan G. M. de VisseriD· 2 shared Abraham OchoaiD· 1 shared Arjen C. van de Peppel· 1 shared Aryan Ramachandran· 1 shared Francisca Reyes MarqueziD· 1 shared Hilje M. DoekesiD· 1 shared Joachim KrugiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Aditi BatraORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Antibiotic tolerance due to filamentation shapes β-lactam pharmacodynamics in Escherichia coli

Aryan Ramachandran, Josia Pool, J. Arjan G. M. de Visser, Hilje M. Doekes, Aditi Batra

This study shows that cefotaxime has a two-step pharmacodynamic curve against E. coli due to filamentation and differential binding to penicillin-binding proteins, offering a mechanistic model for antibiotic action.

bioRxiv · Aug 26, 2026 · PreprintMicrobiology

Experimental evolution of collective β-lactam resistance in Escherichia coli via activation of a dormant outermembrane porin

Abraham Ochoa, Joost Hollander, Rotem Gross, Aditi Batra, Josia Pool, Francisca Reyes Marquez, Arjen C. van de Peppel, Joachim Krug, J. Arjan G. M. de Visser

This study shows that increased collective β-lactam resistance in E. coli arises from activation of a dormant porin, NmpC, through an insertion sequence excision, enhancing drug permeability and filamentation.

bioRxiv · Aug 22, 2026 · PreprintEvolutionary Biology