Quinolinic acid phosphoribosyl transferase moonlights as an apoptosis regulator to empower lung cancer progression
Hossein Kashfi, Didem Ilter, Angelo A. Nicolaci, John H. Lockhart, Stanislav Drápela, Felicia Lazure, Devesh Raizada, Nadir Sarigul, Julia Spegel, Nathan P. Ward, Tumpa Dutta, Stephen J. Gardell, Jennifer M. Binning, Elsa Renee Flores, Gina M. DeNicola, Ana P. Gomes
This study identifies QPRT as a non-canonical apoptosis regulator in NSCLC that suppresses caspase-3 activation, independent of its role in NAD biosynthesis, suggesting it as a therapeutic target.
bioRxiv · Apr 3, 2026 · PreprintCancer Biology