A synthetic xeno-free extracellular matrix surrogate supports robust human induced pluripotent stem cell maintenance and multilineage differentiation
Constantin Berger, Linus Wiora, Terri L. Holmes, Fabiola Walz, Clemens M. Sauter, Luisa Baraban, Julian Schwebler, Geraldine Beer, Sonja Lauke, Jana Keller, Melanie Kraft, Yvonne Schelling, Ka Cheung, Elina Nürnberg, Sarah Al Muthafer, , Daniela Zdzieblo
This study demonstrates that BIOINSTRUCT, a synthetic extracellular matrix surrogate, supports robust human iPSC maintenance and multilineage differentiation comparable to Matrigel.
bioRxiv · Oct 9, 2026 · PreprintCell Biology