Lipopolysaccharide truncation and restoration drives a trade-off in resistance to two phages in Pseudomonas aeruginosa
Ellie J. Tong, Luis M. Bolaños, Julie Fletcher, Robyn Manley, Christian Fitch, Christina Bugert, Jacob Sturgess, James W Sheffield, Rosie Allen, James Graham, N. J. Whitehead, Tom Ireland, Steven L. Porter, Ben Temperton
This study isolates a novel phage targeting the LPS inner core of Pseudomonas aeruginosa and shows that LPS modifications create a trade-off in resistance to two phages, suggesting that combining phages targeting different LPS regions can delay resistance.
bioRxiv · Jan 20, 2026 · PreprintMicrobiology