Molecule-resolved inference reveals the spatial organization of transcriptional programs
Yichen Si, ChangHee Lee, Weiqiu Cheng, M. D. Sweeney, Jeong Hyun Yun, Myungjin Kim, Jun Goo, Jun Hee Lee, Hyun Min Kang
The paper introduces FICTURE2, a statistical model that infers transcriptional programs from individual RNA molecules in spatial transcriptomics data, revealing spatial organization and cellular identity without segmentation.
bioRxiv · Oct 30, 2026 · PreprintGenomics