Molecular principles for graded activation of dopamine D1 receptor
Xinyue Zhang, Yu Zheng, Heng Liu, Jingjing Hou, Luyu Fan, Xinheng He, Jun Sun, Tao Liu, Jianhui Zhou, Ruxin Lei, Mingyang Li, Wen Hu, Xi Cheng, Sheng Wang, Xin Xie, , Youwen Zhuang
The paper defines the molecular mechanism of graded activation of the dopamine D1 receptor and shows how ligand efficacy is encoded through an activation pathway.
bioRxiv · Jul 29, 2026 · PreprintBiochemistry