VPS35/Retromer-dependent MT1-MMP regulation confers melanoma metastasis
Qinggang Hao, Yan Bai, Ruiqi Guan, Rui Dong, Weiyu Bai, Hayam Hamdy, Liqiong Wang, Mingyao Meng, Yan Sun, Junling Shen, Jianwei Sun
This study identifies VPS35/retromer as a regulator of MT1-MMP localization and stability, showing its role in melanoma metastasis and suggesting it as a therapeutic target.
Science China Life Sciences · May 8, 2025Peer-reviewedCancer Biology