Spatial Multi-Omics Reveals Extracellular Matrix Remodeling and VSMC Phenotypic Switching in Moyamoya Disease
Shihao He, Xiaofan Yu, Talha Ahmed, Yaoren Chang, Zhenyu Zhou, Hanzhi Liu, Ying Xu, Junze Zhang, Shaoqi Xu, Lucas Du, Xun Ye, Rong Wang, Yu Zhao
This study uses spatial multi-omics to show ECM remodeling and VSMC phenotypic switching in Moyamoya Disease, linking FN1-ITGA5-FAK pathway activation to metabolic changes in the intimal niche.
bioRxiv · Apr 30, 2026 · PreprintNeuroscience