Author

Justin Thomas

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Elias T. ZambidisiD· 2 shared Ludovic ZimmerliniD· 2 shared Rebecca Evans-Moses· 2 shared Tea Soon ParkiD· 2 shared Alice HeiD· 1 shared Anthony K. L. LeungiD· 1 shared Ariana M. Angarita· 1 shared Clara KochendoerferiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersDevelopmental Biology

Elias T. ZambidisORCID

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2 papers

Recent·Most cited

Proteogenomic Reprogramming to a Functional Human Totipotent Stem Cell State via a PARP-DUX4 Regulatory Axis

Ludovic Zimmerlin, Ariana M. Angarita, Tea Soon Park, Rebecca Evans-Moses, Justin Thomas, Sirui Yan, Isabel R. Uribe, Isabella Vegas, Clara Kochendoerfer, Willem Buys, Anthony K. L. Leung, Elias T. Zambidis

This paper demonstrates that inhibiting PARP1 and Tankyrases in human pluripotent stem cells reprograms them to a totipotent state with lineage-specific gene expression and proteomic changes, mimicking early embryonic development.

bioRxiv · Jun 14, 2024 · PreprintDevelopmental Biology

Vascular Progenitors Generated from Tankyrase Inhibitor-Regulated Naive Diabetic Induced Pluripotent Stem Cells Potentiate Efficient Revascularization of Ischemic Retina

Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Justin Thomas, Jeffrey S. Huo, Riya Kanherkar, Alice He, Nensi Melissa Ruzgar, Rhonda R. Grebe, Imran Ahmed Bhutto, Michael I. Barbato, Michael A. Koldobskiy, Gerard A. Lutty, Elias T. Zambidis

This paper shows that reprogramming diabetic fibroblasts into naive hiPSC using tankyrase inhibitors improves vascular progenitor generation and revascularization in ischemic retinas.

Nature Communications · Mar 5, 2020Peer-reviewedDevelopmental Biology