Genetic diversity of Legionella species in culture-negative clinical and environmental specimens by sequencing the 23S-5S ribosomal intergenic spacer region
Camille M. Jacqueline, Aurélie Peticca, Justine Lannes, Matthieu Curtil-Dit-Galin, Marine Ibranosyan, Laëtitia Beraud, Ghislaine Descours, Sophie Jarraud, Christophe Ginévra
The paper develops a bioinformatic pipeline using 23S-5S rRNA sequencing to identify Legionella species in culture-negative PCR-positive samples, successfully assigning species in 60% of cases and revealing high diversity.
bioRxiv · Sep 19, 2026 · PreprintMicrobiology