Author

K. Buda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

N. Tokuriki· 2 shared A. J. Mulholland· 1 shared C. Frohlich· 1 shared C. M. Miton· 1 shared H. A. Bunzel· 1 shared H.-K. S. Leiros· 1 shared M. W. van der Kamp· 1 shared P. J. Johnsen· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersEvolutionary Biology

N. Tokuriki

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution

C. Frohlich, H. A. Bunzel, K. Buda, A. J. Mulholland, M. W. van der Kamp, P. J. Johnsen, H.-K. S. Leiros, N. Tokuriki

This study shows that epistasis in enzyme evolution arises from shifting the rate-limiting step in the catalytic cycle, leading to substantial activity enhancements through synergistic mutations.

bioRxiv · Jun 29, 2023Evolutionary Biology

Higher-order epistasis creates idiosyncrasy, confounding predictions in protein evolution

K. Buda, C. M. Miton, N. Tokuriki

This study shows that higher-order epistasis causes idiosyncrasy in protein evolution, making predictions unreliable even with epistatic information.

bioRxiv · Sep 7, 2022Evolutionary Biology