Tunnelling nanotubules are druggable mediators of cancer-niche crosstalk.
S. Hockney, J. Parker, B. Tzivelekis, H. Blair, K. Dalgarno, D. Pal
This paper develops a prototype bone marrow-like extracellular matrix and shows that tunnelling nanotubes between leukemia cells and mesenchymal stromal cells are druggable, leading to a triple drug combination with high efficacy.
bioRxiv · Jun 20, 2023 · PreprintCancer Biology