Cancer BiologybioRxiv
BRK Phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG and metastatic potential.
S. Miah, C. Banks, Y. Ogunbolude…·M. P. Washburn
This study shows BRK phosphorylates SMAD4, leading to its proteasomal degradation and inhibition of the tumor suppressor FRK, which promotes metastasis.
DOI 10.1126/sciadv.aaw3113