Author

A. Saraf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

L. Florens· 6 shared C. Banks· 3 shared M. P. Washburn· 3 shared J. Prudhomme· 2 shared K. G. Le Roch· 2 shared S. Abel· 2 shared T. Hollin· 2 shared Z. M. Chahine· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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6 shared papersMicrobiology

L. Florens

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Metastasis-initiating osteosarcoma subpopulations establish paracrine interactions with both lung and tumor cells to create a metastatic niche

J. B. Reinecke, A. Saraf, J. Hinckley, A. C. Gross, H. Le Pommellette, L. Jimenez Garcia, M. Cam, M. V. Cannon, S. Vatelle, B. E. Gryder, R. B. Dries, R. D. Roberts

This study identifies metastasis-initiating osteosarcoma subpopulations that interact with lung and tumor cells to form a metastatic niche, highlighting tumor-stromal interactions as key drivers of metastasis.

bioRxiv · Jun 9, 2024Cancer Biology

Novel 2D/3D Hybrid Organoid System for High-Throughput Drug Screening in iPSC Cardiomyocytes

J. Lewis, B. Yaseen, A. Saraf

The paper develops a 2D/3D hybrid organoid system for high-throughput drug screening in iPSC cardiomyocytes, validated using doxorubicin to assess cardiotoxicity and electrophysiological effects.

bioRxiv · Apr 29, 2024Cell Biology

A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria.

Z. M. Chahine, S. Abel, T. Hollin, J. H. Chung, G. L. Barnes, M. E. Daub, I. Renard, J. Y. Choi, P. Vydyam, A. Chattopadhyay Pal, M. Argomaniz, C. Banks, J. kirkwood, A. Saraf, I. Camino Diaz, , K. G. Le Roch

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

bioRxiv · Nov 21, 2023 · PreprintMicrobiology

PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

Z. M. Chahine, M. Gupta, T. Lenz, T. Hollin, S. Abel, C. Banks, A. Saraf, J. Prudhomme, S. Bhanvadia, L. Florens, K. G. Le Roch

This study shows PfMORC regulates chromatin structure and gene repression in Plasmodium falciparum, essential for parasite survival and a potential target for antimalarial drugs.

bioRxiv · Sep 11, 2023Microbiology

Hypoxic response is driven by the BAF form of SWI/SNF

K. D. Tran, T. Chakravarty, J. Garzon, A. Saraf, L. Florens, M. Washburn, A. Dutta

The paper shows hypoxia alters SWI/SNF complex composition, with BAF subunits retained and others downregulated, affecting HIF target gene induction and cell survival.

bioRxiv · Feb 16, 2022 · PreprintBiochemistry

BRK Phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG and metastatic potential.

S. Miah, C. Banks, Y. Ogunbolude, E. Bagu, J. MacAusland-Berg, A. Saraf, G. Hattem, C. Kempf, M. Sardiu, S. Napper, L. Florens, K. E. Lukong, M. P. Washburn

This study shows BRK phosphorylates SMAD4, leading to its proteasomal degradation and inhibition of the tumor suppressor FRK, which promotes metastasis.

bioRxiv · Dec 7, 2018Cancer Biology

The ULK1-FBXW5-SEC23B nexus controls autophagy

M. Pagano, Y.-T. Jeong, D. Simoneschi, S. Keegan, D. Melville, N. Adler, A. Saraf, L. Florens, M. P. Washburn, C. Cavasotto, D. Fenyö, A. M. Cuervo, M. Rossi

This study identifies the ULK1-FBXW5-SEC23B pathway as a regulator of autophagy by controlling COPII localization and SEC23B stability during nutrient starvation.

bioRxiv · Oct 12, 2018Cell Biology

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation

N. Zhou, A. Gutierrez Uzquiza, X. Y. Zheng, D. Vogl, A. L. Garfall, L. Bernabei, A. Saraf, L. Florens, M. P. Washburn, A. Illendula, J. H. Bushweller, L. Busino

This study identifies RUNX1 and RUNX3 as proteins that protect IKZF1 and IKZF3 from lenalidomide-induced degradation, thereby reducing the effectiveness of lenalidomide in multiple myeloma.

bioRxiv · Sep 20, 2018Cancer Biology