The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering non-imported proteins
K. Knoeringer, C. Groh, L. Kraemer, K. C. Stein, K. G. Hansen, J. M. Herrmann, J. Frydman, F. Boos
The paper shows that mitochondrial membrane proteins accumulate in the endoplasmic reticulum during import defects, triggering the UPRER to maintain protein homeostasis.
bioRxiv · May 19, 2021Cell Biology