Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration
A. L. Nielsen, N. Rajabi, N. Kudo, K. L. Larsen, C. Moreno-Yruela, M. Baek, M. Fontenas, A. Lucidi, A. S. Madsen, M. Yoshida, C. A. Olsen
The paper develops potent, selective SIRT2 inhibitors with features suitable for cell culture and therapeutic development.
bioRxiv · Mar 20, 2020 · PreprintBiochemistry