A Splice Site-Sensing Conformational Switch in U2AF2 is Modulated by U2AF1 and its Recurrent Myelodysplasia-Associated Mutation
C. L. Kielkopf, D. N. Ermolenko, J. L. Jenkins, K. M. Laird, C. F. Feeney, E. Glasser, C. Warnasooriya
This study investigates how U2AF1 and its S34F mutation affect U2AF2 conformational dynamics and RNA binding using single-molecule FRET.
bioRxiv · Dec 31, 2019Biochemistry