Design of a GAK/EGFR inhibitor set to interrogate the relationship of EGFR and GAK in chordoma
C. Asquith, K. Naegeli, M. P. East, T. Laitinen, T. M. Havener, C. I. Wells, G. L. Johnson, D. H. Drewry, W. J. Zuercher, D. C. Morris
The paper designs a set of GAK/EGFR inhibitors to study their relationship in chordoma and characterizes their activity in vitro and through target engagement assays.
bioRxiv · Nov 20, 2018Pharmacology & Toxicology