BiochemistrybioRxiv
Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527
A. Shannon, V. Fattorini, B. Sama…·B. Canard
This paper identifies a protein-priming mechanism for SARS-CoV RNA synthesis and shows that AT-527 inhibits this process by targeting both NiRAN and RdRp domains.
DOI 10.1038/s41467-022-28113-1