E. Decroly

Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2

This study identifies a mechanism by which tick-borne flaviviruses inhibit interferon signaling by targeting TYK2 catalytic activity through their NS5 protein.

Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2' by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2

The paper discusses the implications of spike-glycoprotein processing by Furin and TMPRSS2 on SARS-CoV-2 infectivity and cell entry, but the manuscript has been withdrawn.

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

This study identifies fluoxetine as an inhibitor of the enterovirus 2C AAA+ ATPase, revealing its mechanism of action through structural and functional analyses.

A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases

This paper develops a high-throughput fluorescence polarization assay to screen inhibitors of exoribonucleases from arenaviruses and coronaviruses and validates it with a small compound library.

Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

This paper identifies a protein-priming mechanism for SARS-CoV RNA synthesis and shows that AT-527 inhibits this process by targeting both NiRAN and RdRp domains.

SARS-CoV-2 spike-glycoprotein processing at S1/S2 and S2' and shedding of the ACE2 viral receptor: roles of Furin and TMPRSS2 and implications for viral infectivity and cell-to-cell fusion

This study investigates the roles of Furin and TMPRSS2 in SARS-CoV-2 spike protein processing and viral entry, showing their synergistic effects and suggesting combined inhibitors as antivirals.

Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase

This study shows Favipiravir inhibits SARS-CoV-2 by targeting its RNA polymerase through chain termination, slowed synthesis, and mutagenesis.

In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

This study screens an FDA-approved chemical library to identify potential inhibitors of SARS-CoV-2 replication in vitro, finding several compounds with antiviral potency.