Characterization of immunoactive and immunotolerant CD4+ T cells in breast cancer by measuring activity of signaling pathways that determine immune cell function
Y. Wesseling-Rozendaal, A. van Doorn, K. Willard-Gallo, A. van de Stolpe
The paper measures signaling pathway activity in CD4+ T cells to identify immune tolerant states in breast cancer, finding that Treg cells contribute to immunosuppression and resistance to checkpoint inhibitors.
Cancers · Jan 19, 2022Peer-reviewedCancer Biology