Programmable DNA Assemblies Reconstitute Supramolecular Protein Function
Dhanush Gandavadi, Abhisek Dwivedy, Revathi Manoharaan, Seongmin Im, Saurabh Umrao, Chau Nguyen Minh Hoang, Kadmos Hammoud, Lauren Nguyen, Yang Zhao, Rohit Bhargava, Xing Wang
The paper introduces CASCAD, a DNA nanoplatform that reconstitutes supramolecular protein function, specifically apoptosome activity, through programmable assembly of caspase recruitment domains.
bioRxiv · Sep 17, 2026 · PreprintSynthetic Biology