Decoding isozyme-specific substrate recognition in protein arginine deiminases by proteome-wide citrullination mapping
Sophia Laposchan, Yi‐Fang Yang, Kai-Han Chan, Rebecca Meelker Gonzalez, Wassim Gabriel, Mathias Wilhelm, Hui‐Chih Hung, Chien‐Yun Lee
The paper maps isozyme-specific substrate recognition of PAD1-4 by identifying citrullination sites across the proteome, revealing distinct sequence preferences and key residues determining substrate specificity.
bioRxiv · Dec 3, 2025 · PreprintBiochemistry