A family-aware All of Us benchmark for polygenic prediction and genomic machine learning
Greycen Ren, Kaiden Wu, Christina Ren, Irura Nyiha, Kendall Wu, John Yang
The paper introduces a family-aware benchmark for polygenic prediction using All of Us data, enabling comparison of PRS and machine learning models across 14 traits with strong predictive performance.
medRxiv · Oct 26, 2026 · PreprintGenetic & Genomic Medicine