Single-cell analysis of chromatin silencing programs in developmental and tumor progression
Steven J. Wu, Scott N. Furlan, Anca B. Mihalas, Hatice S Kaya-Okur, Abdullah Hamid Feroze, Samuel Emerson, Ye Zheng, Kalee Carson, Patrick Joseph Cimino, Christopher Dirk Keene, Jay F. Sarthy, Raphaël Gottardo, Kami Ahmad, Steven Henikoff, Anoop P. Patel
This paper develops scCUT&Tag to profile H3K27me3 in single cells, distinguishing cell types in blood and identifying PcG activity changes in brain tumors before and after treatment.
bioRxiv · Sep 4, 2020 · PreprintGenomics