De novo identification of the specificities of recurrent human T cell receptors
Mithila Kasbe, Berkay Yahsi, Kalyn Whitehead, Jiwon Oh, Mashwiyat Mosharraf, Kayla Sohn, Trinh Phan, Mark N. Lee
The paper identifies antigen specificities of public TCRs by screening TCR panels against viral genomes and reference strains, revealing cross-reactive TCRs against coronaviruses, influenza, and herpesviruses.
bioRxiv · Aug 3, 2025 · PreprintImmunology