Cell BiologybioRxivPreprint
Efficiency and localisation of AURKA degradation by PROTACs is modulated by deubiquitinases UCHL5 and target-selective OTUD6A
Annabel Cardno, Karen Roberts, Catherine Lindon
This study identifies deubiquitinases UCHL5 and OTUD6A that modulate AURKA degradation by PROTACs, revealing target-specific and ligase-dependent mechanisms.
DOI 10.1101/2025.04.23.650020