Near-Zero Missed Cleavages with a High-Fidelity Recombinant Arg-C Zero for Mass Spectrometry-Based Proteomics
Cristina Hernandez-Rollan, Jonas Damgaard Elsborg, Elisa Le Boiteux, Yang Lu, Karishma Patel, Ivan Ahel, Ole Nørregaard Jensen, Tanveer Singh Batth, J Olsen
This paper introduces Arg-C Zero, a high-fidelity protease with near-zero missed cleavages, demonstrating its utility in proteomics, especially for analyzing post-translational modifications.
bioRxiv · May 28, 2026 · PreprintBiochemistry