Bootstrat: Population Informed Bootstrapping for Rare Variant Tests
Hailiang Huang, Gina M. Peloso, Daniel Howrigan, Barbara Rakitsch, Carl Johann Simon-Gabriel, Jacqueline I. Goldstein, Mark J. Daly, Karsten Borgwardt, Benjamin M. Neale
Bootstrat corrects population stratification in rare variant tests by using genetic distance to create phenotype probabilities, maintaining statistical power while controlling type I error.
bioRxiv · Aug 11, 2016 · PreprintGenomics