Altering the ribosome exit tunnel to improve consecutive incorporation of challenging monomers
Alexandra D. Kent, Chandrima Majumdar, Katelyn A. Fitzgerald, Alexander Carlos Solivan, Martina Boga de Teresa, J. R. Vance, Alanna Schepartz, Jamie H. D. Cate
This study shows that an A2062U mutation in 23S rRNA improves ribosome activity for translating sequences with challenging monomers like proline and β2-hydroxy acids.
bioRxiv · Jun 2, 2026 · PreprintBiochemistry