U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations
David M. Walter, Katherine Cho, Smruthy Sivakumar, Daniel Denney, Iris TIENLYNN. Lee, Anders B. Dohlman, Jakob M. Heinz, Ethan Shurberg, Kevin X. Jiang, Akansha A. Gupta, Garrett Michael Frampton, Matthew M. Meyerson
This study shows that U2AF1 mutations can rescue exon skipping caused by KRAS mutations in lung adenocarcinoma, revealing a dynamic interplay between splicing factor and oncogenic mutations.
Nature Genetics · Jul 1, 2026Peer-reviewedCancer Biology