Context-specific genetic interaction mapping reveals combinatorial KRAS/FGFR dependence in pancreatic cancer
Richard Y. Ebright, Yao He, Alan G. Zhang, Ian C. McCabe, Chinmaya U. Joisa, Tanay Thakar, Jayu Jen, Dennie Tompers Frederick, Arianny Acosta, Guangyan Li, Elena Kuehner, Vivian Yang, Katherine E Doherty, Natnael Yaregal, Ngan N. K. Van, , William R. Sellers
The paper identifies combinatorial KRAS/FGFR dependence in pancreatic cancer through genetic interaction mapping and shows that combined inhibition overcomes resistance.
bioRxiv · Sep 25, 2026 · PreprintCancer Biology