MYC modulates TOP2A diffusion to promote substrate detection and activity
Donald P. Cameron, Kathryn Jackson, Alessia Loffreda, Carl Möller, Vladislav Kuzin, Matteo Mazzocca, Evanthia Iliopoulou, Hallgerdur Kolbeinsdottir, Andrej Paluda, Evgeniya Pavlova, Bea Jagodic, Brian Saidel Lopez Duran, Valérie Lamour, Fredrik Westerlund, Davide Mazza, Laura Baranello
This study shows MYC enhances TOP2A diffusion, promoting its substrate binding and chromatin engagement, thereby stimulating topoisomerase activity.
Nature Communications · Feb 9, 2026Peer-reviewedCell Biology