Collaborative binding by diverse pioneer transcription factors amplifies Polycomb repression to preserve lineage fidelity
Gerardo Gabriel Mirizio, Morgan Buckley, Katie Ludwig, Satoshi Matsui, Samuel Sampson, Hee‐Woong Lim, Makiko Iwafuchi
The paper shows that PRDM1 collaborates with pioneer TFs to enhance enhancer repression during human endoderm differentiation, preserving lineage fidelity through hyper-bivalent enhancers.
bioRxiv · Sep 11, 2026 · PreprintGenomics