A three-dimensional culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction and disease modeling
Mohsen Afshar Bakooshli, Ethan S Lippmann, Ben Mulcahy, Nisha R Iyer, Christine T Nguyen, Kayee Tung, Bryan A Stewart, Hubrecht van den Dorpel, Tobias Fuehrmann, Molly S Shoichet, Anne Bigot, Elena Pegoraro, Henry Ahn, Howard Ginsberg, Mei Zhen, , Penney M Gilbert
This paper introduces a 3D co-culture model of human skeletal muscle and motor neurons to study adult neuromuscular junction development and disease, showing increased receptor upregulation and disease modeling capability.
bioRxiv · Nov 26, 2018 · PreprintBioengineering