Innate Immune Dysregulation Precedes Clinical Onset in Neuromyelitis Optica
Leonie Müller‐Jensen, Debanjana Chakravarty, Gianmarco Bellucci, Yuan Ding, Michelle Hughes, Alejandro Mejía García, Carson E. Moseley, Ravi Dandekar, JOHN W. ROSE, Lisa K. Peterson, Ka‐Ho Wong, Bradley L. Demarest, Noel G. Carlson, David E. Horvat, Keith Groshans, , Tammy Smith
The paper identifies innate immune activation and CMV-specific antibody reactivity as early markers of preclinical NMOSD, preceding clinical onset by over 12 years.
bioRxiv · Oct 19, 2026 · PreprintImmunology