Author

Kenneth L. Chen

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Matt R. KaeberleiniD· 2 shared Matthew M. CraneiD· 2 shared Adam E. Russell· 1 shared Adrian K. Pun· 1 shared Alan J. HerriD· 1 shared Aleksandra Tsenter· 1 shared Alexandra GolubevaiD· 1 shared Anne BrunetiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMolecular Biology

Matt R. KaeberleinORCID

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Author profile →

3 papers

Recent·Most cited

Sexual reproduction impacts vertebrate organ aging

Jingxun Chen, Aleksandra Tsenter, Emma K. Costa, Doudou Yu, Xiangping Lin, Kenneth L. Chen, Veronica Augustina Bot, Madeline J. Housh, Leo-Paul Heraud, S.V. Perry, Rishad C. Khondker, Michael P. Snyder, Ashley E. Webb, Tony Wyss‐Coray, Anne Brunet

This study shows that lifelong mating in killifish affects liver aging in a sex-specific manner and is associated with younger transcriptomic and proteomic ages in humans.

bioRxiv · Oct 13, 2026 · PreprintGenomics

Loss of vacuolar acidity results in iron sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae

Kenneth L. Chen, Toby N. Ven, Matthew M. Crane, Matthew L. C. Brunner, Adrian K. Pun, Kathleen L. Helget, Katherine Brower, Dexter E. Chen, Ha Doan, Justin D. Dillard-Telm, Ellen Huynh, Yen-Chi Feng, Zili Yan, Alexandra Golubeva, Roy A. Hsu, , Brian M. Wasko

The paper shows that loss of vacuolar acidity in yeast causes iron sulfur cluster defects and divergent iron homeostasis during aging.

GeroScience · Jan 23, 2020Peer-reviewedMolecular Biology

Dynamics of age-related catastrophic mitotic failures and recovery in yeast

Matthew M. Crane, Adam E. Russell, Brent J Schafer, Mung Gi Hong, Joslyn E Goings, Kenneth L. Chen, Ben W. Blue, Matt R. Kaeberlein

This study uses single-cell imaging to examine age-related genome missegregation in yeast, identifying rDNA expansion as a contributor to mitotic failures and nucleolar breakdown.

bioRxiv · Nov 9, 2018 · PreprintCell Biology